Protein Kinase C Epsilon Regulates Gabaa Receptor Sensitivity to Ethanol and Benzodiazepines through Phosphorylation of Γ2 Subunits*
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چکیده
PROTEIN KINASE C EPSILON REGULATES GABAA RECEPTOR SENSITIVITY TO ETHANOL AND BENZODIAZEPINES THROUGH PHOSPHORYLATION OF γ2 SUBUNITS* Zhan-Heng Qi, Maengseok Song, Melisa J. Wallace, Dan Wang, Philip M. Newton, Thomas McMahon, Wen-Hai Chou, Chao Zhang, Kevan M. Shokat, and Robert O. Messing From the Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA, 94608, and the Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143
منابع مشابه
Tyrosine phosphorylation of GABAA receptor γ2-subunit regulates tonic and phasic inhibition in the thalamus.
GABA-mediated tonic and phasic inhibition of thalamic relay neurons of the dorsal lateral geniculate nucleus (dLGN) was studied after ablating tyrosine (Y) phosphorylation of receptor γ2-subunits. As phosphorylation of γ2 Y365 and Y367 reduces receptor internalization, to understand their importance for inhibition we created a knock-in mouse in which these residues are replaced by phenylalanine...
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